Schizophrenia
Conditions
Interventions
Schizophrenia group with first episode or relapse without systemic treatment:medication
Normal control group:none
Sponsors
The Second Affiliated Hospital of Xinxiang Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Both biological parents are Han nationality; 2. Aged 18-55 years, no gender limit; 3. Meet the DSM-IV criteria for the clinical diagnosis of schizophrenia; 4. Total score of PANSS >=60; 5. Written informed consent shall be obtained from the subject. If the subject is incapacitated during the onset period, written informed consent shall be obtained from the legal guardian.
Exclusion criteria
Exclusion criteria: 1. Patients with schizoaffective disorder, mental retardation, generalized developmental disorder, delirium, dementia, memory impairment, or other cognitive impairment who meet the diagnostic criteria of DSM-IV; 2. Mental disorders (alcohol, drugs, etc.) caused by substance abuse, patients with serious unstable physical diseases, diagnosed diabetes, thyroid disease, hypertension, heart disease, etc.; 3. Narrow Angle glaucoma; 4. Patients with a history of epilepsy, except those with high fever and convulsion; 5. Patients who met DSM-IV-TR diagnostic criteria for alcohol and drug dependence (except nicotine dependence); 6. Patients who had been treated with ECT one month before enrollment; 7. Patients with or have suffered from drug-induced malignant symptoms, severe EPS, and obvious delayed dyskinesia; 8. Unable to take medicine according to medical advice, or without guardian; 9. Pregnant or breastfeeding patients, or those planning to become pregnant; 10. The prohibition of magnetic resonance scanning (except those who do not need MRI).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic tools;Social function assessment;Cognitive function assessment;Adverse reaction assessment;Transcriptome detection;Neurophysiological testing;Imaging test;Intestinal flora detection; | — |
Countries
China
Contacts
Public ContactYue Weihua
The Second Affiliated Hospital of Xinxiang Medical College
Outcome results
None listed