Periodontitis
Conditions
Interventions
experimental group:periodontal regeneration
control group:periodontal flap surgery
Sponsors
Stomatological Hospital Affiliated to Nanjing University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who were clinically diagnosed with chronic or invasive periodontitis according to the diagnostic criteria of the 1999 International Classification of Periodontitis; Patients were classified as stage III grade C according to the staging criteria of periodontitis in the 2018 New International Classification of periodontal Disease and peri-implant disease; 2. Aged 18-65 years, no gender limit; 3. Total oral plaque score (FMPS) and total oral bleeding score (FMBS) were less than 15% at baseline; 4. The lesions may involve single or multiple teeth, but the lesions of multiple teeth are not accompanied by root bifurcation lesions; 5. The lesion site requires surgical treatment and meets all the following conditions: (1) PD>=5mm at baseline; (2) After intraoperative debridement, the defect of the lesion site was mainly horizontal bone defect, and only one surface of the lip and buccal surface occurred, and the site could be maxillary or mandibular, and the depth was less than 2mm if there was vertical bone defect; (3) Keratinized gingiva with a width of >=2mm so that bone defects and implants can be completely covered; (4) Radiological examination of horizontal bone defect >=4mm; 6. Tooth loosening <= degree II; 7. Periodontal treatment with etiology (e.g., occlusal trauma) should be completed at least 3 months before screening; 8. The pulp of the test tooth is still viable or has received appropriate pulp treatment.
Exclusion criteria
Exclusion criteria: 1. The test tooth had a history of periodontal surgery; 2. Patients with systemic diseases affecting periodontal healing; 3. A variety of subjects that can lead to oral imaging artifacts, such as: the study tooth and its adjacent teeth are metal dentures, porcelain teeth; 4. Pregnancy or lactation; 5. Patients allergic to recycled materials; 6. Patients who have used drugs affecting periodontal conditions in the past 6 months; 7. Patients with smoking habit, >=10 cigarettes per day; 8. After non-surgical treatment, total mouth plaque score (FMPS) and total mouth bleeding score (FMBS)>=25%; 9. Patients with poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical attachment level; | — |
Secondary
| Measure | Time frame |
|---|---|
| probing depth;gingival recession;bleeding on probing; | — |
Countries
China
Contacts
Public ContactLi Houxuan
Stomatological Hospital Affiliated to Nanjing University School of Medicine
Outcome results
None listed