respiratory syncytial virus pneumonia
Conditions
Interventions
Treatment group:Lianhua Qingwen Granule
Control group:Mimetic Lianhua Qingwen Granule
Sponsors
Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Hospital of Traditional Chinese Medicine)
Eligibility
Sex/Gender
All
Age
1 Years to 14 Years
Inclusion criteria
Inclusion criteria: 1. With reference to the practical pediatrics Zhufutang (8), in line with the western medicine diagnostic criteria for viral pneumonia; 2. Virological examination of RSV: positive (nasopharyngeal secretions of children were collected by colloidal gold method, and positive); 3. Meet the diagnostic criteria of pneumonia, cough and wind-heat pulmonary closure syndrome or phlegm-heat pulmonary closure syndrome in pediatrics of traditional Chinese medicine; 4. Within 5 days of onset; 5. Aged 1-14 years, no gender limit; 6. The legal guardian of the subject gives informed consent. Children aged >=8 years should also sign the children's informed consent form. The process of obtaining informed consent shall comply with GCP regulations.
Exclusion criteria
Exclusion criteria: 1. Suffering from diseases that need to be distinguished from respiratory syncytial virus pneumonia, such as tuberculosis, bacterial pneumonia and other pathogenic microbial pneumonia; 2. Use other antiviral drugs within 1 week before screening, including traditional Chinese medicine with antiviral indications; 3. Severe pneumonia; 4. Judging by the researchers, past or present suffering from illness, may affect the patients to participate in the test or influence the outcome of the study, including: hypertrophic cardiomyopathy, primary immunodeficiency disease, acquired immune deficiency syndrome, congenital respiratory tract malformation, pulmonary dysplasia, aspiration pneumonia, pulmonary malignant tumor diseases; 5. Patients with severe malnutrition, rickets, and severe primary diseases of heart, brain, liver, kidney and hematopoietic system; 6. Allergic constitution, such as allergic to two or more drugs or food, or known allergic to drugs related to this trial; 7. Patients deemed inappropriate for enrollment by other investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| temperature;cough;sputum;shortness of breath (number of breaths);lung auscultation;chest X-ray; | — |
Secondary
| Measure | Time frame |
|---|---|
| remission rate of secondary clinical symptoms;the time to remission of individual symptoms;hospital stay;duration of exacerbation (ICU transfer);incidence of pneumonia complications;combined utilization rate of antibiotics; | — |
Countries
China
Contacts
Public ContactYuan Bin
Jiangsu Province Hospital of Chinese Medicine
Outcome results
None listed