sepsis
Conditions
Interventions
Group 1:Titrate mean arterial pressure
Sponsors
Department of Critical Care medicine, The Fourth Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: According to the Sepsis-3 International Guidelines, patients diagnosed with sepsis upon ICU admission, who require norepinephrine to maintain a MAP >= 65 mmHg after early EGDT resuscitation, and who are aged >= 18 years.
Exclusion criteria
Exclusion criteria: 1. Pregnant women; 2. Patients expected to undergo emergency surgery within 8 hours of sepsis diagnosis; 3. Patients with sepsis complicated by active bleeding; 4. Patients with sepsis complicated by acute cerebral infarction; 5. Patients with sepsis complicated by intracranial hemorrhage and increased intracranial pressure; 6. Patients with sepsis complicated by severe bleeding tendencies, including severe hematologic diseases, hematologic malignancies, and disseminated intravascular coagulation; 7. Patients unable to obtain renal ultrasound images due to surgery, immobilization, or special positioning; 8. Patients in the late stage of disease, expected to die within 24 hours of inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day incidence of AKI;28-day duration of AKI;28-day incidence of CRRT initiation;28-day CRRT-free days;28-day incidence of acute kidney disease;28-day incidence of mechanical ventilation;28-day ventilator-free days;ICU length of stay; | — |
Countries
China
Contacts
Public ContactLiu Lixia
12 Health Road, Chang'an District, Shijiazhuang, Hebei
Outcome results
None listed