Postoperative patient
Conditions
Interventions
2.0 dose group :Fospropofol disodium 10 mg/kg IV, followed by IV infusion of the corresponding dose of fospropofol disodium, target RASS of -3 to 0 points
2.5 dose group :Fospropofol disodium 10 mg/kg IV, followed by IV infusion of the corresponding dose of fospropofol disodium, target RASS of -3 to 0 points
3.0 dose group :Fospropofol disodium 10 mg/kg IV, followed by IV infusion of the corresponding dose of fospropofol disodium, target RASS of -3 to 0 points
3.5 dose group :Fospropofol disodium 10 mg/kg IV, followed by IV infusion of the corresponding dose of fospropofol disodium, target RASS of -3 to 0 points
4.0 dose group :Fospropofol disodium 10 mg/kg IV, followed by IV infusion of the corresponding dose of fospropofol disodium, target RASS of -3 to 0 points
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Those over the age of 18 but under the age of 75; 2. Body mass index BMI 18~30 kg/m2; 3. Those who were transferred to ICU with tracheal intubation after operation; 4. Those who are expected to require mechanical ventilation >= 8 hours, but < 24 hours; 5. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Previously included in this study; 2. Pregnant women; 3. Breastfeeding women; 4. Severe central nervous system diseases (massive cerebral infarction/cerebral hemorrhage; status epilepticus; severe dementia, etc.); 5. This operation is a brain surgery (after aneurysm interventional embolization may not be excluded); 6. Unable to follow orders due to brain trauma before the operation; 7. This operation is a kidney transplant; 8. This operation is a liver transplant; 9. This operation is cardiovascular surgery; 10. Acute hepatitis; 11. Severe liver disease (Child-Pugh C); 12. Chronic kidney disease (CKD grade 3 and above); 13. Myasthenia gravis; 14. Allergic diseases or allergies to study drugs or drugs with similar structures; 15. Unstable angina or acute myocardial infarction; 16. Left ventricular ejection fraction of 30% or less; 17. Heart rate 15ug/kg/min or epinephrine>0.2ug/kg/min or norepinephrine>0.2ug/kg/min) to maintain SBP above 90mmHg; 20. Alcohol or drug withdrawal; 21. Psychopaths.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective dose of fospropofol for postoperative patient sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Richmond Agitation-Sedation; | — |
Countries
China
Contacts
Public ContactYou Shang
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed