Severe craniocerebral injury
Conditions
Interventions
Group 1:Midazolam + remifentanil
Group 2:Midazolam + hydromorphone hydrochloride
Sponsors
Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Head CT diagnosis of craniocerebral injury; 2. Patients with Glasgow Coma Score (GCS) of 3-8; 3. The survival or ICU stay was > 1 week.
Exclusion criteria
Exclusion criteria: 1. Patients with tumors, liver and kidney diseases, gastrointestinal bleeding affecting intestinal flora; 2. Patients with previous gastrointestinal surgery; 3. Patients who took probiotics in the last month or during treatment; 4. There were patients who took antibiotics in the last month; 5. Participate in other intervention researchers; 6. Others: autoimmune diseases, hypothyroidism, Parkinson's disease, past stroke history, major trauma in the previous 2 months; 7. Unqualified fecal sample collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal fatty acid binding protein;D-Lac;Results of fecal high-throughput 16S rRNA gene sequencing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastrointestinal injury; | — |
Countries
China
Contacts
Public ContactZhou Jun
Affiliated Hospital of Southwest Medical University
Outcome results
None listed