Differences in NfL Expression and Degree of Correlation with Disease Progression in Different Clinical Types of MSA

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200057097

Enrollment

Unknown

Registered

2022-02-28

Start date

2022-03-15

Completion date

Unknown

Last updated

2023-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple system atrophy

Interventions

None listed

Eligibility

Sex/Gender

All

Age

40 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 40-75 years old; 2. Patients who meet the diagnosis of probable MSA (probable MSA) in the second edition of the diagnostic criteria proposed by Gilman et al. in 2008, with a clear clinical staging; 3. Able to cooperate in the completion of clinical assessment, venous blood collection, and late follow-up; 4. Voluntary participation in the study and signing of an informed consent form; 5. No cognitive impairment or bed rest at baseline.

Exclusion criteria

Exclusion criteria: 1. Combined history of cerebrovascular disease, history of severe head trauma, and other neuropsychiatric histories; 2. Refusal of follow-up; 3. Family history of ataxia or Parkinson's syndrome.

Design outcomes

Primary

Measure	Time frame
Plasma neurofilament light chain;UMSARS-II;Medical history;Metabolomics;Proteomics;	—

Countries

China

Contacts

Public ContactGuoen Cai

Fujian Medical University Union Hospital

cgessmu@fjmu.edu.cn+86 15860666853

Outcome results