Post-myocardial infarction heart failure
Conditions
Interventions
Experimental group:Nicotinamide
Control group:Base treament
Sponsors
Huadong Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of spontaneous AMI based on the universal MI definition* with randomization to occur between 12 hours and 7 days after index event presentation. (*patients with spontaneous MI event determined to be secondary to another medical condition such as anemia, hypotension, or arrhythmia OR thought to be caused by coronary vasospasm with document normal coronary arteries are not eligible; patients with clinical presentation thought to be related to Takotsubo cardiomyopathy are also not eligible) Evidence of LV systolic dysfunction and/or pulmonary congestion requiring intravenous treatment associated with the index MI event defined as: LVEF = 70 years; (2) eGFR = 18 years of age; 3. Subjects will return to all required follow-up visits, and subjects will comply with protocol requirements; 4. The subjects or their legal representatives signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Hypotension tendency (SBP<90mmHg); 2. Cardiogenic shock, cardiopulmonary arrest, low cardiac output, manifestations of ventricular tachycardia; 3. Psychiatric disorder; 4. Suspected history of HF or persistent new clinical HF pulmonary embolism end-stage renal disease (dialysis or imminent dialysis); 5. Vasodilators are contraindicated for intravenous administration; 6. Allergic to NAD; 7. Normal NT-proBNP levels; 8. Participate in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rates of cardiovascular death and rehospitalization for heart failure;Left ventricular ejection fraction;Left atrial volume;Left ventricular end-diastolic volume;Estimate pulmonary artery pressure; | — |
Countries
China
Contacts
Public ContactZhang Youjun
Huadong Hospital, Fudan University
Outcome results
None listed