Preventive effect of stellate ganglion block on myocardial injury after noncardiac surgery

Preventive effect of stellate ganglion block on myocardial injury after noncardiac surgery: a randomized, controlled, double-blind trials

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200057063

Enrollment

Unknown

Registered

2022-02-27

Start date

2022-03-01

Completion date

Unknown

Last updated

2023-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial injury after noncardiac surgery

Interventions

Experimental group:Ultrasound guided right stellate ganglion block

Control group:Saline

Eligibility

Sex/Gender

All

Age

46 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Older than 45 years old; 2. Cardiac function I-II; 3. Patients underwent elective high-risk surgery in non-cardiac surgery under general anesthesia (the estimated operation time is 3-6h); 4. Informed consent was signed before operation. 5. At least one of the following high-risk factors: (1) History of coronary heart disease; (2) History of stroke or transient ischemic attack; (3) Diabetes requiring drug control; (4) Preoperative renal insufficiency 175 umol/L (>2.0 mg/dl); (5) Peripheral vascular disease; (6) Hypertension requiring medication control; (7) Smoking history in the previous year; (8) Older than 65 years old.

Exclusion criteria

Exclusion criteria: 1. Allergic to local anesthetic drugs; 2. Anatomical abnormalities of the anterior neck or cervical spine; 3. BMI>30 kg/m2; 4. Patients with severe hypertension (more than 180/100mmHg); 5. Pregnant woman; 6. Active heart disease; 7. Preoperative high-sensitivity troponin (hsTnT) >=65ng/L; 8. Patients with arrhythmia or other contraindications; 9. Right heart failure caused by pulmonary embolism; 10. Sepsis, systemic inflammatory response syndrome; 11. The anesthesiologist determined that there was an important coagulation disorder.

Design outcomes

Primary

Measure	Time frame
Incidence of myocardial injury after noncardiac surgery;	—

Secondary

Measure	Time frame
General condition of patients;The operation time;Intraoperative blood loss;Incidence of ECG-ST changes within 48 hours after operation;Incidence of serious adverse cardiovascular events within 48 hours after operation;30-day mortality after surgery;Incidence of recurrent laryngeal nerve block;VAS score and remedial pain rate;	—

Countries

China

Contacts

Public ContactWanyou He

First People's Hospital of Foshan

he_wanyou@qq.com+86 18038862159

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026