Septic acute kidney injury
Conditions
Interventions
Low intensity net ultrafiltration group:Low intensity net ultrafiltration
Middle intensity net ultrafiltration group:Middle intensity net ultrafiltration
High intensity net ultrafiltration group:High intensity net ultrafiltration
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years old; 2. Evidence of sepsis(patients with infection or suspected infection, SOFA score increased by >= 2 points from baseline); 3. Evidence of AKI based on at least one of the following three criteria: (1) Creatinine increased by >=0.3 mg/dl(>=26.5umol/l) within 48 hours; (2) Creatinine rises to =1.5 times baseline within 7 days; (3) Urine output <0.5ml/kg and lasted for 6 hours; 4. The clinician judges that renal replacement therapy is required.
Exclusion criteria
Exclusion criteria: 1. Patients with end-stage renal disease receiving maintenance hemodialysis or peritoneal dialysis; 2. Had a kidney transplant within the past year; 3. Received point-of-care renal replacement therapy in another treatment unit prior to admission to the ICU; 4. The researchers judged it inappropriate to participate in the study (Expect death within 48 hours; CRRT is expected to last less than 24 hours; The patient refused active treatment); 5. Participated in other clinical trials within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Medical history;Baseline laboratory test;Net ultrafiltration volume;Creatinine;90-day mortality;1-year mortality;RRT dependence; | — |
Countries
China
Contacts
Public ContactJin Lin
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed