Neutropenia in preterm infants
Conditions
Interventions
High dose group:rhG-CSF 10 ug/kg injected intravenously
Low dose group:rhG-CSF 5 ug/kg injected intravenously
Control group:rhG-CSF was not injected, or saline was injected
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The premature infants with neutropenia treated in the neonatal intensive care unit of our hospital from January 2022 to December 2023 were selected; 2. Gestational age < 34 weeks; 3. Check the ANC of peripheral blood at least once a week; 4. ANC of peripheral blood < 1.5*10^9/L for at least 24 hours; 5. The clinical data are complete and reliable.
Exclusion criteria
Exclusion criteria: 1. Children with extremely unstable vital signs; 2. Failure to complete diagnosis and treatment as required after enrollment; 3. Due to loss of follow-up or death, the "peripheral blood ANC shall be rechecked at least once a week for 4 weeks" was not completed; 4. Parents refused to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neutrophil count;The number of days from treatment to ANC >1.5*10^9/L in peripheral blood;Total amount of rhG-CSF injected intravenously;The proportion of peripheral blood ANC <1.5*10^9/L again within 4 weeks;Incidence of sepsis;Incidence of other suppurative infections;All-cause mortality rate; | — |
Countries
China
Contacts
Public ContactLi Li
Xuzhou Central Hospital
Outcome results
None listed