Mammary cancer
Conditions
Interventions
Group E:Intravenous injection of 0.25mg/kg esmketamine
Group N:Intravenous injection of equal volume normal saline
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Premenopausal adult women; 2. Able to fill out the depression rating form under guidance; 3. ASA ?- ?; 4. Preoperative radiotherapy and chemotherapy were not performed; 5. Those who meet the ethical requirements, voluntarily undergo the test and sign the informed consent; 6. Have not participated in other clinical drug trials within the last month.
Exclusion criteria
Exclusion criteria: 1. Anti-depression treatment within the last 2 months; 2. Previous personality disorder, intellectual impairment, brain injury or brain disease, combined with schizophrenia, mania and other mental diseases; 3. Combination of immune system diseases, or the use of drugs that have a significant effect on the immune system; 4. Pregnancy or lactation; 5. Alcohol addiction; 6. Hypertension patients with poor blood pressure control after treatment or without regular treatment; 7. Glaucoma patients; 8. Patients with intracranial tumor; 9. Patients with cerebrovascular diseases; 10. Allergic to research drug ingredients; 11. Chronic use of sedatives and painkillers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient Health Questionnaire-9 (PHQ-9) Score;Visual Analogue Scale Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Concentration of BDNF in serum; | — |
Countries
China
Contacts
Public ContactHuang Wan
Sun Yat-sen University Cancer Center
Outcome results
None listed