deaf
Conditions
Interventions
Index test:Sanger sequencing of GJB2 and SLC26A4.
Gold Standard:Fetal DNA was obtained by invasive prenatal testing such as amniocentesis.
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
Female
Age
25 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. The probands of deafness families had definite deafness causative genes (GJB2, SLC26A4); 2. Couples were determined to have a deafness conflict genotype; 3. Both couples were carriers of common deafness genes (GJB2, SLC26A4).
Exclusion criteria
Exclusion criteria: 1. The mother herself is known to have chromosomal number or structural abnormalities; 2. Received exogenous blood transfusion, stem cell transplantation, immunotherapy within 1 year; 3. With comorbid tumor carriage; 4. Those who could not complete prenatal diagnosis on request; 5. With multiple gestations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactJiang Yi
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed