Allergic rhinitis
Conditions
Interventions
Gold Standard:1. Patients diagnosed as CRSwNP according to the diagnostic criteria recommended in the European position document on sinusitis and nasal polyps
2. Patients with allergic rhinitis (according to ARIA standard), or serum specific IgE reached grade 3 or above in skin prick test.
Index test:1. Main outcome measures: kappa coefficient of rhinitis classification of rhinitis patients diagnosed by traditional method and confirmed by kit test during the screening period.
2. Seconda
(2)
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
3 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 3 years and <= 60 years old; 2. Patients who meet any of the following criteria: (1) Patients diagnosed as CRSwNP according to the diagnostic criteria recommended in the European position document on sinusitis and nasal polyps; (2) Patients with allergic rhinitis (according to ARIA standard), or serum specific IgE reached grade 3 or above in skin prick test; 3. The patient agrees to participate in this trial and sign the informed consent form; 4. The patients who met the requirements of the program were judged by the researchers.
Exclusion criteria
Exclusion criteria: 1. Patients with nasal mucosal erosion, nasal mucosal ulcer and nasal septum perforation were found by nasal examination; 2. Patients using anticoagulants within 5 days; 3. Nasal surgery for nearly one month; 4. Other nasal diseases that may lead to drug deposition in the nasal cavity, such as sinusitis, drug-induced rhinitis, nasal polyps or nasal structural abnormalities; 5. Patients with non-allergic rhinitis (vasomotor rhinitis, eosinophilic rhinitis); 6. Screening patients who underwent nasal surgery within 90 days before the start of the observation period; 7. Patients with contraindications for desensitization treatment; 8. Patients with recurrent epistaxis; 9. Patients with complications such as severe liver disease, kidney disease, heart disease or blood disease; 10. There is alcohol or drug abuse/addiction, which may affect patients with research progress. Alcoholism is more than 14 units of alcohol consumed per week (1 unit of alcohol = 360 mL beer, 45 mL spirits or 150mL wine with an alcohol concentration of 40%); 11. Systemic or local use of antibiotics, nasal spray hormones, nasal spray or oral antihistamines within 1 week before sampling, and systemic use of corticosteroids or immunosuppressants 3 weeks before sampling; 12. Upper respiratory tract infection or other acute infection within 30 days.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Eosinophil count of nasal secretions;Detection of ECP/MPO in nasal secretions;Serological test;Subjective symptom score; | — |
Primary
| Measure | Time frame |
|---|---|
| Kappa coefficient of rhinitis typing in patients diagnosed by kit test during screening period;Classification of rhinitis in patients with rhinitis diagnosed by traditional methods in screening period; | — |
Countries
China
Contacts
Public ContactZezhang Tao
Renmin Hospital of Wuhan University
Outcome results
None listed