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Cytokine analysis of aqueous humor and tear about microvascular retinopathy and cytomegalovirus retinitis in HIV/AIDS patients

Cytokine analysis of aqueous humor and tear about microvascular retinopathy and cytomegalovirus retinitis in HIV/AIDS patients

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200056955
Enrollment
Unknown
Registered
2022-02-24
Start date
2017-01-01
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

AIDS

Interventions

AIDS group:
Control group:

Sponsors

Beijing You 'an Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: 1. Meet the 1993 Centers for Disease Control and Prevention (CDC) diagnostic criteria for AIDS; 2. The diagnosis of CMVR meets the following criteria: typical fundus findings (yellow-white retinal lesions with creamy tomato paste, with granular margins or toxoplasma retinitis, with or without bleeding, no or mild vitreous opacity) and laboratory tests (CD4+T cell count less than 200 /ul) with or without CMV antigenemia and/or positive CMV-specific IgM antibodies; 3. Hiv-associated retinal microangiopathy was diagnosed according to the following criteria: fundus presentation cotton patch, retinal hemorrhage, and those microangiopathy that did not progress, expand, or interfere with vision. Except microvascular lesions caused by other systemic diseases.

Exclusion criteria

Exclusion criteria: 1. History of intraocular surgery or intraocular laser; 2. In addition to retinal microvascular disease giant cell retinitis, there are other inflammatory or vascular eye diseases; 3. Glaucoma; 4. Recent systemic and/or topical use of glucocorticoids Drugs; 5. HIV-infected patients who have received local or systemic anti-cytomegalovirus therapy; 6. Has systemic inflammatory disease.

Design outcomes

Primary

MeasureTime frame
Aqueous cytokines;Tear cytokines;Ultra wide-angle fundus photography;CD4 T lymphocytes;Ocular Surface Analyzer;blood HIV viral load;

Countries

China

Contacts

Public ContactWenjun Kong

Beijing You'an Hospital, Capital Medical University

drkongwenjun@163.com+86 18611786833

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 11, 2026