Clinical efficacy of SSRIs in patients with first-episode depression based on serum c-reactive protein levels

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200056949

Enrollment

Unknown

Registered

2022-02-24

Start date

2022-03-01

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depression disorder

Interventions

Depression CRP normal group:Sertraline

Depression group with elevated CRP:Sertraline

Depression group with elevated CRP:bupropion

Eligibility

Sex/Gender

Male

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria for depression in ICD-10 Diagnostic Criteria; 2. First attack; 3. Aged 18-60; 4.17 Hamilton Depression Rating Scale (HAMD-17) scores>17; 5. Exclude depressive attacks caused by physical diseases, trauma and other diseases; 6. Deny serious physical diseases; 7. Male; 8. CRP > 5mg/L or 0-5mg/L; 9. With the consent of the family member or patient, sign the relevant informed consent form.

Exclusion criteria

Exclusion criteria: 1. Those who are unwilling to cooperate in continuing treatment and voluntarily withdraw; 2. The disease is aggravated; 3. Serious adverse reactions.

Design outcomes

Primary

Measure	Time frame
CRP;HAMD(17);	—

Countries

China

Contacts

Public ContactMa Zengming

Xiamen Xianyue Hospital

809061992@qq.com+86 13306017301

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026