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Exploring the spatiotemporal distribution and biological mechanism of TCM syndromes in diabetic kidney disease based on systems biology technology

Exploring the spatiotemporal distribution and biological mechanism of TCM syndromes in diabetic kidney disease based on systems biology technology

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200056935
Enrollment
Unknown
Registered
2022-02-23
Start date
2022-03-01
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetic kidney disease

Interventions

no:no

Sponsors

Wangjing Hospital of China Academy of Chinese Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1 Inclusion criteria for diabetic kidney disease: 1) Meet the diagnostic criteria of Western medicine 2) Aged 30-85 years old 3) Blood pressure=150/90mmHg 4) Glycated hemoglobin=8.5% 5) eGFR=25ml/min: 2 Inclusion criteria for diabetes: ?Meet the diagnostic criteria of DM; ?Age between 30-85 years old; ?Blood pressure=150/90mmHg; ?Glycated hemoglobin=8.5%.

Exclusion criteria

Exclusion criteria: 1 Exclusion criteria for diabetic kidney disease 1)Blood pressure<90/60mmHg; 2) Serum creatinine doubled in the past six months; 3) Unilateral or bilateral renal artery stenosis; 4) Serious macrovascular events occurred in the past six months; 5) Combined with serious diseases such as malignant tumor and hematological diseases; 6) There are serious psychological or mental disorders; 7) Pregnant or lactating women; 8) Considering other kidney diseases (such as urinary tract infection, urinary sediment activity (red blood cells), etc.), renal biopsy is required to confirm the diagnosis; 9) Those who have undergone dialysis or kidney transplantation. 2 diabetes exclusion criteria 1) Complications of diabetes; 2) Blood pressure<90/60mmHg; 3) Serious macrovascular events occurred in the past six months; 4) Combined with serious diseases such as malignant tumor and hematological diseases; 5) There is a serious psychological or mental disorder; 6) Pregnant or lactating women.

Design outcomes

Primary

MeasureTime frame
Glycated hemoglobin;24-hour urine protein quantification;Albumin creatinine ratio;Serum creatinine;urea nitrogen;Transcriptomics;Proteomics;metabolomics;

Countries

China

Contacts

Public ContactZhang Ning

Wangjing Hospital of China Academy of Chinese Medical Sciences

znice3927@126.com+86 13910610038

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026