Postoperative delirium
Conditions
Interventions
control group:Saline
Sponsors
The General Hospital of Western Theater Command
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Age =60 years; 2.ASA grade I~III; 3.BMI=28kg/m2; 4.planned to undergo radical esophagectomy under general anesthesia; 5.signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are contraindicated for intranasal administration (such as nasal cavity defects or lesions); 2. Have hypertension and diabetes in the past; Have a history of insulin allergy; Have a history of alcoholism; 3. Unable to communicate before operation (coma, deep dementia or language disorder, severe visual and hearing impairment); 4. The MMSE score is too low [illiteracy<17 points, primary school level<20 points, secondary school level (including technical secondary school)<24 points]; 5. History of serious heart, liver and kidney disease, nervous system disease or mental disease; 6. Withdrawal criteria: insulin was used by other means than nasal route during the test; 7. Perform operation again within 3 days after operation; 8. Unexpected adverse events (such as drug allergy, anesthesia and surgical accidents); 9. The patient lost the follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total incidence of POD in 3 days;miRNA-490-3P;Neurog2; | — |
Secondary
| Measure | Time frame |
|---|---|
| age;gender;body mass index;Educational level;Operation time;ASA classification;Preoperative hemoglobin concentration;Intraoperative blood loss;Intraoperative blood transfusion;NRSIscale;Coefficient of variation of blood glucose; | — |
Countries
China
Contacts
Public ContactHuang Qingqing
Outcome results
None listed