A Multi-Center Clinical Study Based on Multimodal Magnetic Resonance Imaging of Primary Headache Disorders

Primary headache multimodal magnetic resonance imaging multicenter prospective cohort study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200056871

Enrollment

Unknown

Registered

2022-02-22

Start date

2022-02-22

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary headache

Interventions

Case series:None

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 18 and 65 years, right-handed; 2. Migraine diagnosed according to the International Classification of Headache Disorders, third edition, tension-type headache, cluster headache, new daily persistent headache, drug overdose headache, and headache duration of more than 1 year; At the same time, healthy subjects matched with age, sex and education level were included; 3. Subjects sign the informed consent voluntarily.

Exclusion criteria

Exclusion criteria: 1. Use prophylactic medication for headache in the past month; Take painkillers, sedatives, sleeping pills, coffee, alcohol and other drugs that affect your mental state 12 hours before the scan; 2. Accompanied by other types of chronic pain, paresthesia, history of craniocerebral trauma, history of craniocerebral surgery, and severe mental and psychological diseases; 3. A history of systemic diseases such as hypertension, diabetes, coronary atherosclerotic heart disease and cerebrovascular disease requires long-term medication; 4. Installation in vivo heart pacemakers, artificial heart valve, metal electronic cochlea, chemotherapy pump and drugs such as insulin pump pump, intraocular foreign body metal, the brain aneurysm clips, coronary stent, a variety of intravascular stent and filter, all kinds of artificial joints and prosthesis, inside the metal holder, dentures, orthodontic orthoses or retainer, and hair dye, eyebrow tattoo, tattoo patients; 5. Pregnant or breastfeeding; 6. Claustrophobic; 7. Patients with brain lesions (such as ischemia, cyst, etc.) by magnetic resonance examination; 8. Others are not suitable for this study.

Design outcomes

Primary

Measure	Time frame
Brain multimodal magnetic resonance imaging;	—

Secondary

Measure	Time frame
Case report form;Patient Health Questionnaire Depression Self-Rating Scale;GAD-7 Anxiety Disorder Screening Scale;Migraine Burden Assessment Scale (MIDAS);PSQI;	—

Countries

China

Contacts

Public ContactDong Zhao

Chinese PLA General Hospital

dong_zhaozhao@126.com+86 10 55499318

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026