Nasopharygneal carcinoma
Conditions
Interventions
Experimental group:radiation therapy
Sponsors
Cancer Center, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. At initial diagnosis and histopathological diagnosis, the pathological type was non-keratinizing carcinoma (according to the World Health Organization, WHO pathological classification). 2. Staging is III-IVa (according to the eighth edition of AJCC Staging standards). 3. No evidence of distant metastasis (M0). 4. Functional status: Karnofsky scale (KPS) > 70. 5. Normal bone marrow function: white blood cell count > 4x10^9/L, hemoglobin > 90g/L and platelet count > 100x10^9/L. 6. Normal liver function: total bilirubin = 60 mL/min(according to Cockcroft-Gault formula) or serum creatinine = 50% (according to RECIST, version 1.1), plasma EBV DNA decreased to 0 copies/mL. 9. Patients must be informed of the basic content of the study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. The pathological type was WHO keratinizing squamous cell carcinoma or basal squamous cell carcinoma. 2. Aged > 65 years or < 18 years. 3. Treatment is palliative. 4. Previous history of malignant tumor. Exceptions are adequately treated basal or squamous cell carcinoma of the skin and carcinoma in situ of the cervix. 5. Pregnant or lactating patients (consider pregnancy tests for women of child-bearing age; Effective contraception should be emphasized during treatment). 6. Previous radiation therapy (except for non-melanoma skin cancer with previous lesions outside the radiation target area).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;Incidence of acute and late toxiciity;Quality of life;Local replase-free survival; | — |
Countries
China
Contacts
Public ContactMao Yanping
Sun Yat-sen University
Outcome results
None listed