Type 2 diabetes, obesity
Conditions
Interventions
Without the Polyethylene glycol, Loose, the peptide:With the Polyethylene glycol, Loose, the peptide
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. (1999 WHO diagnostic criteria) confirmed type2 diabetes and GLP-1 indications (2017 version of CDA diagnosis and treatment guide) 2. only after diet adjustment and exercise treatment, or a stable dose oral hypoglycemic drug single medicine or two drug combination At least 3 months 3. 20-65 ye.ars old, gender unlimited 4. BMI19-35kg / m2, hba1c7.5 -11.0 5. fasting blood sugar 7.0-10.0mmol / L 6. sign informed consent 7. and strictly abide by clinical trial plan
Exclusion criteria
Exclusion criteria: 1. polyethylene glycol ropeptide injection skin test positive 2. has received GLP-1 agonist, DPP-4 inhibitor 3. hypertension history After the treatment of antihypertensive drugs, shrink pressure> 160mmHg and / or diastolic pressure> 100mmHg 4. serious cardiovascular disease patients 5. patients with diabetic ketoacid or nona keto hyperglycemia - hypertonic coma or severe hypoglycemia, patients with severe diabetes complications, patients with diabetes, monochrome mutant diabetes, 2 multiple Diabetes or secondary diabetes patients with endocrine injury, patients with pancreatic injury, human historic patients, inflammatory bowel disease and diabetic gastrointestinal paralysis patients, episodes of patients with pancreatitis, end-stage nephropathy Patients with severe liver function impaired (Glycoprine aminotransferase> 60 u / L or aspartate aminotransferase> 60U / L). 6. Data incomplete perspective, unwilling partners, pregnant women or lactating women 7 research adult can't complete research or bring obvious risks to subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting blood glucose;Blood sugar 2 hours after meal;Glycated hemoglobin;liver function;Renal function;Blood lipid;ß-hydroxybutyrate;C peptide;insulin;Glucagon;Urine microely protein than creatinine;Blood routine;Urinary routine;System measurement;Eye base;Islet function; | — |
Secondary
| Measure | Time frame |
|---|---|
| body weight;Waist circumference;Hip;Waist button ratio;Pleat thickness;blood pressure;Rhythm;Heart rate;Electrocardiogram;Carotid ultrasound;Abdominal ultrasound;Thyroid ultrasound;Echocardiography;Oxidative stress correlation index; | — |
Countries
China
Contacts
Public ContactZhang Xiujuan
Outcome results
None listed