Pharmacokinetics and Personalized therapy of midazolam for sedation in Chinese Children

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200056773

Enrollment

Unknown

Registered

2022-02-15

Start date

2022-02-17

Completion date

Unknown

Last updated

2023-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy, convulsion

Interventions

case series:N/A

Eligibility

Sex/Gender

All

Age

1 Years to 13 Years

Inclusion criteria

Inclusion criteria: 1. Patients under continuous sedation with midazolam due to trauma, infection and mechanical ventilation in pediatrics and pediatric intensive care unit of our hospital; 2. More than 2 blood samples and 1 cerebrospinal fluid examination were preserved during sedation treatment.

Exclusion criteria

Exclusion criteria: 1. Irregular medication; 2. Samples deterioration or contamination; 3. Insufficient on sedation effects or medication records; 4. Lackness of renal function or biochemical index data.

Design outcomes

Primary

Measure	Time frame
Drug concentration;liver and kidney function;Ramsay score;	—

Countries

China

Contacts

Public ContactLei Feng

Department of Pharmacy, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China

294549679@qq.com+86 159 6377 9039

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026