Postoperative delirium in one-lung ventilation
Conditions
Interventions
Group F:100 mg flurbiprofen 10 ml
Group C:Placebo 10 ml
Sponsors
First Affiliated Hospital of USTC
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria were as follows: (1) age between 65 and 75 years; (2) American Society of Anesthesiologists (ASA) status ?-III; and (3) anticipated duration of one-lung ventilation greater than 60 minutes.
Exclusion criteria
Exclusion criteria: Exclusion criteria were as follows: (1) severe impairment of respiratory function (forced expiratory volume in 1 second of less than 50% of the predicted values); (2) presence of contraindications for using flurbiprofen or intralipid; (3) treatment with NSAIDs drugs within 1 month before surgery; (4) scored<24 on the Mini-mental State Examination (MMSE) or who were unable to complete baseline cognitive assessment; (5) History of smoking, alcohol or drug abuse; (6) difficult to maintain oxygenation with one-lung ventilation intraoperatively; (7) duration of one-lung ventilation was smaller than 60 minutes; (8) unable to collect data due to the cerebral oximeter machine malfunction; (9) researchers believe that other situations do not meet the conditions of this study. For example, VATS was intraoperatively converted to an open thoracotomy procedure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the mean absolute rScO2 values and AUT-rScO2; | — |
Countries
China
Contacts
Public ContactDi Wang
Outcome results
None listed