Allergic rhinitis with adenoid hypertrophy
Conditions
Interventions
Control group:Loratadine for 1 month and isotonic nasal saline for 2 months
Test group:Loratadine (1 month) combined with spleen Aminopeptide Oral Solution (2 months), isotonic nasal saline for 2 months
Sponsors
Affiliated pediatric hospital of Fudan University
Eligibility
Sex/Gender
All
Age
3 Years to 12 Years
Inclusion criteria
Inclusion criteria: (1) 3 = age < 12 years, male or female; (2) Meet the diagnostic criteria of allergic rhinitis; (3) According to the diagnostic criteria of clinical adenoid hypertrophy, children with nasal degree II or above after adenoid obstruction were confirmed by nasal endoscopy, and the lateral X-ray of nasopharynx showed that the ratio of the maximum thickness of adenoid to the distance between the anterior and posterior diameter of nasopharynx (A / N) was 0.61 = A / N = 0.80; (4) The history of nasal congestion, cough and snoring is more than 3 months; (5) Patients who had not received other similar immunomodulatory drugs within 4 weeks; (6) No systemic hormone therapy was used within 3 months; (7) Volunteer to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Adenoidectomy was performed; (2) Rhinosinusitis associated with tonsillar hypertrophy, including nasal polyps, hypertrophy of inferior turbinate, severe deviation of nasal septum, nervous and muscular tension of the meatus, nasal masses, retrogression of the root of the tongue, and obstructive symptoms caused by obesity; (3) Acute upper and lower respiratory tract infection in recent 2 weeks; (4) Children with metabolic and immune deficiency diseases and severe organic diseases such as heart, liver, kidney and brain; (5) Patients considered unsuitable by the investigator for clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A / N ratio of adenoid hypertrophy;Endoscopic evaluation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptom score(VAS);Drug score; | — |
Countries
China
Contacts
Public ContactXu ZhengMin
Affiliated pediatric hospital of Fudan University
Outcome results
None listed