To explore the relationship between nociceptive stimulation index (qnox) and postoperative cognitive function in the elderly

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200056713

Enrollment

Unknown

Registered

2022-02-11

Start date

2022-02-28

Completion date

Unknown

Last updated

2023-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty

Interventions

Experimental group:Total knee arthroplasty under general anesthesia and femoral nerve block

Control group:Total knee arthroplasty under general anesthesia

Eligibility

Sex/Gender

All

Age

60 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Patients to undergo total knee arthroplasty; 2. American Society of anesthesiologists (ASA) grade II - III; 3. Age >= 60 years old; 4. Body mass index (BMI): 18.5 - 29kg / m2; 5. Estimated length of stay >= 7 days.

Exclusion criteria

Exclusion criteria: 1. Patients with cognitive impairment, mental illness, or dementia before operation; 2. Patients with severe organic diseases (coronary heart disease, bronchial asthma, severe hypertension, severe blood system dysfunction, liver and kidney function, and electrolyte abnormalities); 3. Have a long-term history of sedative or analgesic abuse; 4. Those who have participated in clinical trials of other drugs in recent 4 weeks.

Design outcomes

Primary

Measure	Time frame
Postoperative Cognitive Dysfunction;Pain NRS score;QoR40 score;	—

Secondary

Measure	Time frame
CRP;IL-6;Cortisol;	—

Countries

China

Contacts

Public ContactWang Sheng

Anhui Provincial Hospital

iamsheng2020@ustc.edu.cn+86 19156007726

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026