Tourette's syndrome
Conditions
Interventions
Probiotic intervention group:Oral Bifidobacterium longum CICC p0001, Lactobacillus plantarum p-8, Bifidobacterium infantum CICC 6069, Lactobacillus reuteri CICC 6132 mixture
Placebo group:Placebo
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Age: 6-12 years old; 2. Children's Tourette syndrome was diagnosed by children's neuropsychiatric doctors; 3. Be able to cooperate in the inspection of various scales; 4. No history of respiratory and digestive tract infection in recent 1 month; 5. No probiotic taking history in recent 1 month; 6. No history of digestive system diseases or other chronic diseases; 7. Return to the hospital on time.
Exclusion criteria
Exclusion criteria: 1. Patients with previous immune system diseases; 2. Patients with a previous history of central nervous system infection; 3. Patients with previous metabolic diseases; 4. Those who cannot tolerate drug treatment; 5. After informed consent, the parents refused to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Yale Global Tic Severity Scale score;Clinical remission of tic disorders;Changes of bacterial flora and metabolites; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remission of other comorbidities;SNAP-IV;CY-BOCS;PRS;Conduct Disorder/Oppositional Defiant Disorder Inventory; | — |
Countries
China
Contacts
Public ContactGuang Yang
Chinese PLA General Hospital
Outcome results
None listed