Changes in brain function
Conditions
Interventions
Group 1 :Phase I: Progressive sedation of remazolam toluenesulfonate, Phase II: Progressive sedation of propofol.
Group 2:Phase I: Progressive sedation of propofol
Phase II: Progressive sedation of remazolam toluenesulfonate.
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Healthy volunteers; 2. Age 18-65 years, no gender limitation; 3. ASA I-II; 4. BMI 18-26 kg/m2; 5. Agreed to participate in this study and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Participated in other clinical trials within 4 weeks prior to the beginning of this study; 2. Being pregnant or planning to become pregnant; 3. Women in the lactation stage; 4. Have a history of neurological or mental diseases; 5. People who drink heavily and take large doses of sedatives for a long time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional connectivity of the brain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Independent component analysis; | — |
Countries
China
Contacts
Public ContactGong Cansheng
Fujian Provincial Hospital
Outcome results
None listed