Carbapenem-resistant gram-negative bacterial infection
Conditions
Interventions
None:Treated with polymyxin B
Sponsors
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. = 18 years old; 2. CRO infected persons confirmed or suspected to be diagnosed by clinical and microbiological culture, mNGS and other new technologies; 3. Patients treated with polymyxin B intravenously; 4. Participate in the study voluntarily and sign the informed consent form; If the subject has no ability to understand or sign the informed consent form, his/her legal representative will act as his/her agent for the informed process and allow him/her to participate in the study; If the subject is illiterate, the witness is required to witness the informed process and decide to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Those with positive CRO culture and no evidence of infection; 2. Pregnant or nursing; 3. Those who only use polymyxin B locally (e.g. intraventricular administration, inhalation, etc.); 4. Those who have used or combined with polymyxin E sulfate or polymyxin E sodium methanesulfonate before using polymyxin B; 5. Patients with polymyxin B for less than 3 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma concentration;pharmacokinetic parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| efficacy;nephrotoxicity;28-day mortality; | — |
Countries
China
Contacts
Public ContactYu Yunsong
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University
Outcome results
None listed