Helicobacter pylori
Conditions
Interventions
A group:home-made esomeprazole 20mg qid+amoxicillin 750mg qid for 14 days
B group:brand-name esomeprazole(Nexium) 20mg qid+amoxicillin 750mg qid for 14 days
Healthy controlled group:None
Sponsors
Department of Gastroenterology,Nanjing First Hospital
Eligibility
Sex/Gender
All
Age
23 Years to 61 Years
Inclusion criteria
Inclusion criteria: 1.Ages between 18 and 65 years; Sexes eligible for study: both; 2.patients who are diagnosed with Helicobacter pylori; 3.treatment-naive patients or patients who failed to eradicate Helicobacter pylori in the past but haven't undergone eradication therapy in the past six months; 4.voluntary to be involved in the study and written informed consent was obtained from all patients.
Exclusion criteria
Exclusion criteria: 1. Allergy to the study drug (penicillin allergy, etc.); 2. Patients with chronic gastritis and peptic ulcer; 3. Patients who have received Helicobacter pylori eradication treatment within half a year; 4. Antibiotics, bismuth and probiotics were used 4 weeks before the start of the study, and histamine H2 receptor antagonists, PPI or potassium competitive acid blockers were used in the first 2 weeks; 5. Use of corticosteroids, non-steroidal anti-inflammatory drugs or anticoagulants; 6. History of esophageal or gastric surgery; 7. Pregnant women and lactating women; 8. Suffer from serious concomitant diseases, such as liver disease, cardiovascular disease, lung disease, kidney disease and tumor; 9. Excessive drinking.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| H.pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction assessment;Tongue coating microbiota;Gut microbiota; | — |
Countries
China
Contacts
Public ContactZhenyu Zhang
Nanjing First Hospital
Outcome results
None listed