Severe Aplastic Anemia
Conditions
Interventions
1:IST+rhTPO+Etrapropa
Sponsors
Henan Cancer Hospital
Eligibility
Sex/Gender
All
Age
4 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age = 4 years old, = 70 years old; 2. ECOG score = 2 (Appendix 2); 3. There are clear blood routine, reticulocyte count, multi-site bone marrow puncture, bone marrow biopsy and other results to diagnose AA; 4. The patient's main tissues and organs function well: 1) Cardiac function: there is no heart disease or coronary heart disease, and the patient's cardiac function is 1-2 (Appendix 3); 2) Liver function: TBIL = 3ULN, AST = 2.5ULN, ALT = 2.5ULN; 3) Renal function: Cr = 1.25ULN; 5. The patient's peripheral superficial venous blood path is smooth, which can meet the requirements of intravenous infusion; 6. There are no other serious diseases (such as autoimmune diseases and immune deficiency) that conflict with this program; 7. History of other malignant tumors.
Exclusion criteria
Exclusion criteria: 1. Suffering from systemic active infection requiring treatment; 2. Those suffering from serious heart, liver, kidney dysfunction and other diseases; 3. HIV-infected patients; 4. Suffering from serious autoimmune diseases or immune deficiency diseases; 5. Severe allergic constitution; 6. Serious mental disorders; 7. Those who have participated in or are currently participating in other clinical trials in the past three months; 8. Previously received standard IST treatment or allogeneic hematopoietic stem cell transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR; | — |
Countries
China
Contacts
Public ContactXinjian Liu
Tumor Hospital of Henan Province
Outcome results
None listed