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A comparative study on the effect of different hepatoprotective drug regimens in patients with abnormal liver function caused by anti-tuberculosis drugs

A comparative study on the effect of different hepatoprotective drug regimens in patients with abnormal liver function caused by anti-tuberculosis drugs

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200056610
Enrollment
Unknown
Registered
2022-02-09
Start date
2022-02-07
Completion date
Unknown
Last updated
2024-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

drug-induced liver injury

Interventions

Liver protection program 1 group:none
joint programme group:none

Sponsors

Beijing Chest Hospital,Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Diagnosis of various types of tuberculosis; 2. Diagnosis of liver injury/liver damage/abnormal liver function/hepatic insufficiency/increased transaminase/hyperbilirubinemia, etc.; 3. Test items ALT, AST, ALP, TBIL Other indicators are abnormal; 4. Hepatoprotective drugs are used. If 1 and any one of 2, 3, and 4 are satisfied, it will be included.

Exclusion criteria

Exclusion criteria: 1. Anti-tuberculosis drug RUCAM score < 3 points. 2. Incomplete information or lack of key information such as the results of liver biochemical tests and the use of liver-protecting drugs. 3. Combined viral liver disease/alcoholic liver disease/non-alcoholic fatty liver disease/autoimmune liver disease/cholestatic disease/genetic metabolic liver disease. 4. Combined with other diseases that may cause abnormal liver biochemical indicators.

Design outcomes

Primary

MeasureTime frame
ALT;TBIL;ALP;

Countries

China

Contacts

Public ContactLiuShuo

Beijing Chest Hospital,Capital Medical University

liushuo80@126.com+86 10 89509092

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026