Obesity
Conditions
Interventions
Remazolam group 1:Low dose Remazolam
Remazolam group 2:Medium dose Remazolam
Remazolam group 3:High dose Remazolam
Alfentanil group 1:Low dose Alfentanil
Alfentanil group 2:Medium dose Alfentanil
Alfentanil group 3:High dose Alfentanil
Esmketamine group 1:Low dose Esmketamine
Esmketamine group 2:Medium dose Esmketamine
Esmketamine group 3:High dose Esmketamine
Sponsors
He'nan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who intend to undergo painless gastroenteroscopy; 2. Aged 18-65 years, no gender limit; 3. Body fat percentage (PBF) >20% in males and >28% in females; 4. American Society of Anesthesiologists (ASA) Grade I-III.
Exclusion criteria
Exclusion criteria: 1. Patients who refused to participate in the trial; 2. Patients with a history of severe heart, brain, lung, liver, kidney and metabolic diseases; 3. Patients with previous abnormal surgical anesthesia recovery history; 4. Electrocardiogram: heart rate 180mmHg and/or diastolic blood pressure >110mmHg in hypertensive patients, or < 90/60mmHg in hypotensive patients; 7. Patients with neuromuscular system diseases or mental diseases; 8. Anemia patients; 9. Suspected abuse of narcotic analgesics or sedatives; 10. Those who are predicted to have or have had difficult airway; 11. Known allergy to emulsions and opioids; 12. Uncooperative and unable to communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs;Effectiveness index;Ramsay sedation score;BPS - NI behavior improved pain rating scale; | — |
Countries
China
Contacts
Public ContactLiu Shengqun
He'nan Provincial People's Hospital
Outcome results
None listed