Parkinson's disease (PD)
Conditions
Interventions
Experimental group :theta burst stimulation +multidisciplinary intensive rehabilitation therapy (TBS+MIRT)
Control group:sham-theta burst stimulation +multidisciplinary intensive rehabilitation therapy ( sham-TBS+MIRT)
Sponsors
Beijing Rehabilitation Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria for primary Parkinson's disease; 2. H-y stage 2-4; 3. Aged 45-75 years; 4. Patients who have used drugs for more than 2 weeks without adjustment and have not undergone DBS surgery; 5. Can walk without assistance (including auxiliaries).
Exclusion criteria
Exclusion criteria: 1. Cognitive, motor and speech disorders caused by other neurological disorders; 2. History of epilepsy or other contraindications for transcranial magnetic stimulation; 3. Unwilling or unable to participate in MRI examination (claustrophobia); 4. Severe cognitive impairment or audio-visual impairment, unable to communicate and cooperate with the examination; 5. Serious concomitant diseases such as heart, lung, liver and renal insufficiency; 6. Unable to cooperate to complete the training or inspection; 7. Failure to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parkinson's Disease Unified Rating Scale(III); | — |
Secondary
| Measure | Time frame |
|---|---|
| Parkinson’s Disease Questionnaire-39;Levodopa equivalent dose;Neuroelectrophysiology;Functional MRI;Brain-derived neurotrophic factor;Neuron-specific enolase;Serum homocysteine; | — |
Countries
China
Contacts
Public ContactJin Zhaohui
Beijing Rehabilitation Hospital Affiliated to Capital Medical University
Outcome results
None listed