Tic disorder
Conditions
Interventions
Intervention group:Clonidine
Control group:None
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Aged 6-12 years; 2. Tic disorders diagnosed by a child neuropsychiatrist; 3. Be able to complete the examination of various scales; 4. Not taking any medication for tic disorders; 5. No history of other chronic diseases; 6. Return to the hospital on time.
Exclusion criteria
Exclusion criteria: 1. Current use of medications for tic disorders other than clonidine; 2. Suspected mental retardation, accompanied by heart, brain, liver, kidney organ diseases; 3. Allergic to ingredients contained in clonidine and transdermal patches; 4. Had taken antipsychotic drugs, antidepressants, antimanic drugs and anticonvulsants within 1 week before enrollment; 5. A history of rheumatic chorea, epilepsy, childhood headache, mental retardation, schizophrenia, or a history of immune system diseases, central nervous system infections and metabolic diseases; 6. Rheumatic chorea, epileptic myoclonic seizures, drug-induced involuntary twitch and vocalization; 7. Weight <= 20 kg; 8. Parents rejected participants after informed consent was given.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Yale tic scale score;Blood metabolomics test;Brain function status; | — |
Secondary
| Measure | Time frame |
|---|---|
| Snap - ? parental questionnaire score;CY-BOCS scale score;PRS scale score;Conduct disorder / oppositional defiance disorder scale score; | — |
Countries
China
Contacts
Public ContactYang Guang
Chinese PLA General Hospital
Outcome results
None listed