Helicobacter pylori infection
Conditions
Interventions
Control group:Placebo + standard quadruple therapy
Experimental group:Probiotics + standard quadruple therapy
Sponsors
The First People's Hospital of Kunshan
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-60 years, no gender limit; 2. Positive C13 urea breath test, rapid urease test, serum Hp antibody or histological examination; 3. Good compliance, able to comply with the requirements of clinical trials; 4. The subject or guardian has signed the informed consent form, basic information questionnaire, and promised to cooperate with the study throughout the trial period.
Exclusion criteria
Exclusion criteria: 1. Patients previously treated with Helicobacter pylori; 2. Patients who had taken antibiotics, proton pump inhibitors, bismuth preparations and some traditional Chinese medicine with antibacterial effect 4 weeks before enrollment; 3. Those who had taken probiotics, prebiotics or synbiotics 2 weeks before enrollment; 4. Previous digestive system surgery (except appendectomy, polypectomy and cholecystectomy); 5. Eradication of allergy or any contraindications with quadruple antibiotic therapy; 6. Severe mental or neurological disorders; 7. Alcohol or drug abusers; 8. Pregnant women or breast-feeding patients; 9. Failed to adhere to treatment and participated in other clinical investigators; 10. Participated in other clinical trials within 4 weeks before enrollment; 11. The doctor judged that the compliance was poor and it was not suitable to participate in the clinical investigator after evaluation; 12. Relevant personnel of this clinical trial study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate;Microbiota analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of side effects;Patient compliance; | — |
Countries
China
Contacts
Public ContactWu Xiaoyang
Outcome results
None listed