None listed
Conditions
Interventions
Group 1:Esketamine, dexmedetomidine and tropisetron
Group 2:Sufentanil, dexmedetomidine and tropisetron
Group 3:Dexmedetomidine, tramadol and tropisetron
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
19 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists (ASA) Class I-III; 2. Aged 19-65 years, skilled in PCA pump application; 3. Understand and fully cooperate with postoperative scoring tools.
Exclusion criteria
Exclusion criteria: 1. Body mass index (BMI)>30kg/m^2; 2. A history of angina pectoris or myocardial infarction in the past 6 months; 3. Patients with poorly controlled or untreated hypertension (resting systolic/diastolic blood pressure >180/100 MMHG); 4. Untreated or undertreated hyperthyroidism; 5. Patients with liver and kidney dysfunction; 6. Patients with neuropsychiatric disorders; 7. Chronic alcoholics; 8. Long-term use of sedative, hypnotic and analgesic drugs; 9. Heart rate < 50 beats/min or degree III atrioventricular block; 10. Known allergy to test drugs such as dexmedetomidine or/and esketamine; 11. Change the operation method during the operation; 12. Loss of perioperative patient data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nausea and vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale pain score;Ramsay sedation score;BCS comfort score;Mean arterial pressure;Heart rate;Breathing rate;SpO2; | — |
Countries
China
Contacts
Public ContactLi Xiaoxia
The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed