Osteoarthritis of the knee
Conditions
Interventions
Group B:Ropivacaine+adrenaline+dexamethasone+magnesium sulfate
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who need unilateral primary TKA operation due to severe knee osteoarthritis; 2. Aged 20-80 years; 3. The preoperative American Society of Anesthesiologists (ASA) rating (anesthesia risk assessment) is I-III.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to anesthetic drugs and sulfonamides; 2. There are more than moderate knee joint deformity (valgus, flexion deformity) and joint stiffness; 3. Those who drink excessively or take opioids for a long time; 4. Patients with language disorder and unable to complete the numerical rating scales (NRS) of pain; 5. Neuropathy of extremities on the operative side; 6. Psychotic patients; 7. Patients with previous digestive tract ulcer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first postoperative remedial analgesia;Postoperative dosage of remedial morphine hydrochloride; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analog score for pain;Range of knee motion;Quadriceps strength;Incidence of postoperative complications;Daily walking distance;The duration of hospital stay;Inflammatory indicators; | — |
Countries
China
Contacts
Public ContactKang Pengde
West China Hospital, Sichuan University
Outcome results
None listed