Diabetic nephropathy (DN)
Conditions
Interventions
Experimental group:Mesenchymal stem cell intravenous injection+standardized treatment measures
Control group:Standard treatment
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with early diabetic nephropathy were selected according to the World Health Organization (WHO) diagnostic criteria for type 2 diabetes in 1999 and Mogensen and other DN staging criteria; 2. Gender is unlimited, aged 30-65 years; 3. Urine albumin excretion rate (UAER) of at least 2 consecutive times within 6 months is 20-200 µg/min (30-300 mg/24h), glomerular filtration rate (GFR) 70-30 mL/min, or continuous urine protein<0.5 g/24h, serum creatinine (SCR) and creatinine clearance rate (CCr) were within normal range; 4. The patient has received renal biopsy within 6 months, and the pathological diagnosis is consistent with DN, or although no renal biopsy is performed, the clinical diagnosis is consistent with DN; 5. The patient has good compliance and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Participated in other clinical trials within 30 days before the start of this study; 2. Pregnant or lactating patients; 3. Plasma albumin (ALB)= 160mmHg or diastolic blood pressure >= 100mmHg) and it is difficult to control; 7. Complicated with urinary tract infection, ketoacidosis, heart failure (heart failure), pulmonary infection and tumor; 8. Use of nephrotoxic drugs; 9. Have a history of mental illness or other incompatibility factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| albumin;24 hours urine protein quantification; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood sugar; | — |
Countries
China
Contacts
Public ContactLiu Gang
The Second Hospital of Shandong University
Outcome results
None listed