septic shock
Conditions
Interventions
Control group:None
Experimental group:Intravenous infusion of methylene blue
Sponsors
The First People's Hospital of Yunnan Province (Affiliated Hospital of Kunming University of Science and Technology)
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: The patient met the diagnostic criteria for sepsis, and on this basis was accompanied by continuous hypotension. After full fluid resuscitation, vasoactive drugs were still needed to maintain the mean arterial pressure at 65 mmHg or above, and the blood lactate concentration was>2 mmol/L.
Exclusion criteria
Exclusion criteria: 1. Pregnant patients; 2. Glucose 6-phosphate dehydrogenase deficiency; 3. Patients with methemoglobinopathy or acute cyanide poisoning caused by drugs containing or producing aromatic amines such as nitrite, nitrate, aniline, nitrobenzene in recent 3 days; 4. Patients allergic to methylene blue; 5. Those who quit midway due to changes in their condition and did not complete volume resuscitation; 6. Aged <18 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lactic acid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral vascular resistance index;Central venous oxygen saturation;Mean arterial pressure; | — |
Countries
China
Contacts
Public ContactFan Chuming
The First People's Hospital of Yunnan Province
Outcome results
None listed