Parkinson's disease
Conditions
Interventions
Group 1:High frequency repetitive transcranial magnetic stimulation + Madopa
Group 2:Medoba treatment alone and false stimulation
Sponsors
Jingzhou First People's Hospital (the First Hospital Affiliated Clinical Medical College, Yangtze University)
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Criteria for inclusion in the "end of dose phenomenon" study group: 1. According to the diagnostic criteria of Parkinson's disease in the British brain bank, the diagnosis of primary Parkinson's disease is Hoehn Yahr stage 2 - 4; 2. The survey of "end of agent phenomenon" 9 questionnaires (woq-9) was positive. Criteria for inclusion in the "switching phenomenon" study group: 1. According to the diagnostic criteria of Parkinson's disease in the British brain bank, the diagnosis of primary Parkinson's disease is Hoehn Yahr stage 2 - 4; 2. There are clinical manifestations in open and closed stages.
Exclusion criteria
Exclusion criteria: 1. Dementia; 2. Serious mental illness; 3. Epilepsy; 4. Patients with bleeding tendency; 5. Severe heart disease; 6. Patients with severe hypertension and severe heart, liver, lung and kidney failure; 7. Serious alcohol abusers; 8. Those with metal implants in the brain, such as vascular stents, coil brain pacemakers, cardiac metal membranes, cardiac pacemakers and cochlear implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Activity of daily living score;Motor function score;Daily occurrence frequency of powder phenomenon;Frequency of switching phenomenon;Time of opening;Time of closing period; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse event;Anxiety;Depression; | — |
Countries
China
Contacts
Public ContactLuo Zhijian
Jingzhou First People's Hospital (the First Hospital Affiliated Clinical Medical College, Yangtze University)
Outcome results
None listed