postoperative neurocognitive disorders
Conditions
Interventions
Group A:single bolus of 20 mg/kg IV-TXA diluted 100ml before skin incision
Group B:normal saline in total 100 ml volume intravenous administration before operation.
Sponsors
The Fourth Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 65 to 80 years old, no gender limit; 2. Patients who plan to undergo non-cardiac and non-neurosurgical surgery under general anesthesia; 3. No tranexamic acid taboo; 4. All patients were screened with a Informant Questionnaire on Cognitive Decline (IQCODE) > 51, Montreal cognitive assessment (MoCA) (MoCA <= 13(illiterate), MoCA <= 19(primary school), MoCA <= 2(Middle school or above)), Clinical Dementia Rating (CDR) of 0.5 points, and fully capable of basic activities of daily living those were identified with mild cognitive impairment (MCI) before the surgery; 5. All patients have the ability to act in full spirit, understand and sign the informed consent, and are willing to complete the whole research process.
Exclusion criteria
Exclusion criteria: 1. Planned use of systemic TXA during surgery; 2. Preoperative hepatic or renal dysfunction; 3. Preoperative use of anticoagular medication seven days prior to surgery; 4. History of fibrinolytic disorder or blood dyscrasia; 5. Cerebrovascular accident, myocardial infarction, New York heart association class III or IV heart failure, atrial fibrillation, history of deep vein thrombosis or pulmonary embolus; 6. History of seizure disorder; 7. In the last 3 months, they have participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative cognitive dysfunction;Systemic inflammation level;Intraoperative blood loss; | — |
Countries
China
Contacts
Public ContactQi Sihua
The Fourth Affiliated Hospital of Harbin Medical University
Outcome results
None listed