Diarrhea and constipation in infants
Conditions
Interventions
Intervention for diarrhea:Probiotics for 5 days
Intervention for constipation:Probiotics for 28 days
Control for diarrhea:Placebo for 5 days
Control for constipation:Placebo for 28 days
Sponsors
Xiangya School of Public Health, Central South University
Eligibility
Sex/Gender
All
Age
No minimum to 3 Years
Inclusion criteria
Inclusion criteria: 1. Infants aged 3 to 36 months; 2. Diagnosed as diarrhea or constipation in infants; 3. Parents or primary guardians can read and write Chinese; 4. Informed consent of parents or primary guardian. Among them: infant diarrhea: defined as painless defecation >= 3 times a day, and the stool is not formed or liquid stool. Infant constipation: meet at least 2 of the following symptoms, lasting at least 1 month: 1. The number of defecation is less than or equal to 2 times per week; 2. History of massive fecal retention; 3. History of pain and difficulty in defecation; 4. History of fecal discharge; 5. There are a large number of fecal masses in the rectum; The following additional criteria may be used for children who have learned to defecate: 6. Stool incontinence at least once a week after learning to defecate; 7. There is a history of fecal discharge, and it may even cause toilet blockage.
Exclusion criteria
Exclusion criteria: 1. Do not reside locally; 2. With malnutrition, severe dehydration, severe systemic disease (such as encephalitis, sepsis, pneumonia), immunodeficiency, severe liver and kidney function and cardiopulmonary function, an abnormal spirit, food allergies, and other diseases of the digestive system (intestinal malformations, bowel surgery, short bowel syndrome, inflammatory bowel disease, congenital malformation gastrointestinal tract, etc.); 3. Use broad-spectrum antibiotics or any antidiarrheal drugs >= 3 days within 2 weeks before enrollment; 4. Use probiotics and prebiotics before enrollment; 5. Poor medication compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota;Infant diarrhea cure rate;Infant constipation cure rate; | — |
Countries
China
Contacts
Public ContactLin Qian
Xiangya School of Public Health, Central South University
Outcome results
None listed