Patent ductus arteriosus in preterm infants
Conditions
Interventions
Acetaminophen group:Acetaminophen
High dose ibuprofen group:High dose ibuprofen
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Gestational age = 1.5 mm, left atrial inner diameter / aortic root >= 1.5, diastolic descending aortic reflux; (3) It has one of the following clinical manifestations: systolic murmur, increased precordial pulsation, water rushing pulse, increased pulse pressure difference and deterioration of respiratory condition.
Exclusion criteria
Exclusion criteria: 1. Children with extremely unstable vital signs, congenital heart disease relying on arterial catheter opening, persistent pulmonary hypertension, etc.; 2. The clinical data are unreliable or incomplete, as well as children whose parents refuse diagnosis and treatment, discharge automatically, death and so on; 3. The family members of the child refused to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum cystatin C; | — |
Secondary
| Measure | Time frame |
|---|---|
| PDA closure rate after conservative management;Incidence of adverse reactions after rescue treatment; | — |
Countries
China
Contacts
Public ContactGao Xiangyu
Xuzhou Central Hospital
Outcome results
None listed