Balanced Opioid-free Anesthesia with Dexmedetomidine and Esketamine for Hip Surgery in the Elderly

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200056421

Enrollment

Unknown

Registered

2022-02-05

Start date

2022-01-31

Completion date

Unknown

Last updated

2024-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hip fracture

Interventions

Group opioid anesthesia:Anesthesia with opioids

Group opioid-free anesthesia:Anesthesia with non-opioid medicine

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged 60 years and over; 2. Elective hip surgery; 3. ASA physical statusI-III.

Exclusion criteria

Exclusion criteria: 1.Inability to consent to the study; 2.Allergy to any of the drugs used in the study; 3.Contraindication to regional anesthesia; 4.Cardiac, hepatic and renal insufficiency; 5.Atrioventricular block, intra-ventricular or sinoatrial block and HR < 50 bpm; 6.Uncontrolled hypertension; 7.Contraindication to the use of a2A-agonist and esketamine; 8.Preoperative oxygen saturation below 95%; 9.Mental Disorder, major depression, schizophrenia or dementia; 10.Severe visual or auditory disorder.

Design outcomes

Primary

Measure	Time frame
Postoperative opioid-related adverse events;	—

Secondary

Measure	Time frame
Pain score;Postoperative nausea and vomiting;Dose of propofol;Dose of vasoactive drugs;Adverse events (hypertension, hypotension, bradycardia);Depth of Sedation;Length of hospital stay after surgery;30 days postoperative all-cause mortality;	—

Countries

China

Contacts

Public ContactZhang Ye

The Second Hospital of Anhui Medical University

zhangye_hassan@sina.com+86 13966768081

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026