Osteoarthritis and sarcopenia
Conditions
Interventions
Group 1:Plant dipeptide protein powder
Group 2:Plant protein
Group 3:Maltodextrin
Sponsors
Jinhua Wenrong Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Men and women with OA&SA who were 50 to 70 years old with a K&L rating of mild or moderate (grade 1 or 2) and who met the SARC-CalF rating; 2.During the study, subjects agreed not to take any drugs, supplements, or performance enhancers; 3.During the study, subjects agreed not to participate in any OA&SA-related physical therapy; 4.Subjects are willing to comply with all research requirements and procedures; 5.Subjects have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Subjects in other similar studies on dairy or probiotic products in the last 6 months; 2.Currently taking medication for cardiovascular or metabolic diseases; 3.Subjects had flu/virus symptoms within 3 months prior to first visit to laboratory; 4.Have any of the following medical history or be diagnosed to have the following diseases: obvious gastrointestinal disorders, liver, kidney, endocrine, blood, respiratory and cardiovascular diseases, which may affect the evaluation of the study results; 5.Current or historical abuse of alcohol or prohibited performance-enhancing drugs, supplements, or prescription OTC drugs; 6.Suffer from any gastrointestinal disorders or gastrointestinal diseases, including but not limited to allergic bowel syndrome, enteritis, ulcerative colitis, celiac disease; 7.Within 3 months prior to screening or currently receiving medical or nutritional treatment, including protein supplementation or the use of substances that provide exercise capacity; 8.Weight gain or weight loss of more than 5KG in the 3 months before screening; 9.History of hospitalization 3 months prior to screening; 10.In the judgment of the investigator, there is frequent use of medications that may affect electrolyte balance or hydration. ;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Grip strength;Short Physical Performance Battery (SPPB);Western Ontario and McMaster Universities Osteoarthritis Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| MRI;DXA;Inbody;Chalder Fatigue Scale (CFQ 11);SARC-CalF;SF36;Biochemical indicators; | — |
Countries
China
Contacts
Public ContactWu Tao
Sprim (Shanghai) Consulting Co., Ltd.
Outcome results
None listed