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Effect of multimodal analgesia on perioperative anesthesia and prognosis in breast surgery patients

Effect of thoracic nerve block combined with esketamine anesthesia on perioperative anesthesia and early prognosis in breast disease patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200056391
Enrollment
Unknown
Registered
2022-02-04
Start date
2022-02-01
Completion date
Unknown
Last updated
2024-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast disease

Interventions

control group:traditional anesthesia
PS group:thoracic nerve block combined with esketamine

Sponsors

Department of Anesthesiology, Cangzhou Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1. Female patients with modified radical mastectomy for breast cancer under elective general anesthesia in our hospital; 2. Aged 18 to 64 years; 3. ASA grade I-II; 4. BMI: 18-25 kg/m2.

Exclusion criteria

Exclusion criteria: 1. Hypertension grade III; 2. Coronary heart disease; 3. Pulmonary hypertension; 4. Hyperthyroidism; 5. Intracranial hypertension; 6. Glaucoma; 7. Using monoamine oxidase inhibitor; 8. Infection at the puncture site; 9. History of chronic pain; 10. Pain medication wihin 24 hours before surgery; 11. History of mental and psychological diseases; 12. History of adverse reactions to ketamine treatment; 13. History of local anesthesia drug allergy; 14. History of lung disease; 15. Obvious abnormality in preoperative chest CT; 16. Language and communication barriers.

Design outcomes

Primary

MeasureTime frame
OAA/S score;NRS score;Anxiety and Depression Score;Satisfaction score;Anesthetic dosage;Recovery Quality Score;Serum inflammatory cytokines;BDNF;5-HT;Sleep Quality Score;Cognitive function;emergence agitation;—

Countries

China

Contacts

Public ContactCui Xiuling

Department of Anesthesiology, Cangzhou Central Hospital

Zhangbo19970418@163.com+86 15103172870

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026