Melasma
Conditions
Interventions
treatment group:ruby fractional laser
control group:Q-Switched Nd:YAG Laser
Sponsors
Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Female, aged 18 to 50 years; 2. Meeting the diagnostic criteria for melasma in the "Diagnostic Criteria for Melasma and Vitiligo (2010 Edition)"; 3. Symmetrically distributed on the face with similar degree, extent and color; 4. Patients agree to participate in the study and sign the Informed Consent Form.
Exclusion criteria
Exclusion criteria: 1. Patients with chronic skin diseases or skin tumors on the face; 2. Laser treatment is contraindicated (e.g. patients with photosensitive dermatoses, photo-aggravated dermatoses, light-related skin malignancies, and photosensitive drug takers, etc.); 3. Patients received other treatments within 6 months (including but not limited to drugs, lasers, intense pulsed light, mesotherapy, chemical peels and other therapeutic measures); 4. Patients with serious liver, kidney, cardiovascular, respiratory, hematopoietic diseases and malignant tumors; 5. Pregnancy and lactation; 6. Patients who are taking anticoagulants, contraceptives, sex hormones, thyroxine and other drugs, which may affect the assessment of efficacy; 7. Patients who cannot protect themselves from the sun and light after therapy; 8. Patients with mental illness; 9. Patients who are unwilling to provide medical history information or do not accept follow-up; 10. There are other conditions that the investigator considers unsuitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Melasma area severity index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Physician Global Assessment;Patient satisfaction;Safety evaluation; | — |
Countries
China
Contacts
Public ContactZhao Yi
Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Outcome results
None listed