Helicobacter pylori infection
Conditions
Interventions
Dual therapy:Vonolasheng-Amoxicillin: Vonolasheng 20mg bid, amoxicillin 1g tid, course of treatment for 14 days
Triple therapy:Vonolasheng-Amoxicillin-Clarithromycin: Vonolasheng 20mg bid, amoxicillin 1g bid, clarithromycin 0.5g bid, treatment course for 14 days
Quadruple Therapy:Esomeprazole-Tetracycline-Metronidazole-Bismuth Potassium Citrate: Esomeprazole 20mg bid, tetracycline 500mg tid, metronidazole 400mg tid, bismuth potassium citrate 0.6g (containing
Sponsors
The University of Hong Kong Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Over 18 years old and less than 75 years old; 2. From December 2021 to December 2022, patients aged 18-75 years who were confirmed to have Hp infection in the outpatient clinic of Shenzhen Hospital of the University of Hong Kong through a 13C urea breath test were the subjects of the study. Hp infection diagnosis method: 13C urea breath test (=4) positive can be judged as Hp infection;
Exclusion criteria
Exclusion criteria: Previous Hp eradication treatment, history of gastric surgery, pregnant women, lactating women, gastric malignant tumors or other serious systemic diseases, antibiotics, bismuth or other drugs that may affect Hp in the past 4 weeks (Including traditional Chinese medicine or probiotics), have used acid suppressants in the past 2 weeks, have used macrolide antibiotics repeatedly or for a long time, or are allergic to any of the drugs in the trial protocol, have used antiplatelet drugs such as aspirin or Anticoagulant drugs such as warfarin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Negative or positive; | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptom remission rate=(number of cases before treatment - number of cases after treatment)/number of cases before treatment × 100%;Drug compliance=Amount taken/amount prescribed * 100%;analysis of drug use cost; | — |
Countries
China
Contacts
Public ContactLyu T ao
The University of Hong Kong Shenzhen Hospital
Outcome results
None listed