overweight or obesity
Conditions
Interventions
control:Normal diets and unrestricted feeding time
Intervention group 1:Healthy low-carbohydrate diet and unrestricted feeding time
Intervention group 2:Normal diet and time-restricted feeding
Intervention group 3:healthy low-carbohydrate diet and time-restricted feeding
Sponsors
Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Overweight or obesity (BMI >= 24); 2. Aged between 20 and 60 years; 3. Sedentary or mildly or moderately physical active.
Exclusion criteria
Exclusion criteria: 1.Potential participants were excluded if they performed overnight shift work more than once a week; 2.Regularly fasted (defined as fasting 15 hours per day or having completed twelve 24-hr fasts within the past year); 3.On a low-carbohydrate diet or special or prescribed diet for other reasons in the past 3 months; 4.Significant changes in body weight in the past 3 months (>=3kg); 5.Currently enrolled in a weight loss or weight management program or taking any medication that has a known effect on appetite; 6.Had severe digestive disease, gastrointestinal surgery, or impaired nutrient absorption, or history of an eating disorder; 7.Currently had acute or chronic diseases (including diabetes or a significant cardiovascular, renal, cardiac, liver, lung, or nervous system disease), cancer, or any infectious disease; 8.Received any operation treatment in the prior 3 months or a plan to accept surgery in 3 months; 9.Took antibiotics, anti-diabetes medications, steroids, beta-blockers, adrenergic-stimulating agents, or other medications that could affect the study endpoints in the prior 3 months; 10.Took dietary supplement in the last 3 months (including omega-3 fatty acids, prebiotics, probiotics, plant sterols/steroids); 11.Uncontrolled psychiatric disorder or inability to understand or follow instructions; 12.Regularly performed heavy physical activity; 13.Active tobacco abuse or alcohol abuse; 14.Pregnant, breast-feeding, or have a plan to pregnant within three months; 15.Currently participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting Glucose;Weight; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;C-reaction protein;Gut microbiota;Triglyceride;Total cholesterol;High-density lipoprotein;Low-density lipoprotein;Height;Fat mass;Lean mass;Waist circumference;Hip circumference; | — |
Countries
China
Contacts
Public ContactLiu Gang
Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed