multiple myeloma
Conditions
Interventions
A:Boanmycin combined with low-dose dexamethasone
B:Boanmycin combined with classic drugs (PI, iMIDs or cytotoxic drugs)
Sponsors
Longgang District People’s Hospital of Shenzhen
Eligibility
Sex/Gender
All
Age
10 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1. Patients who diagnosed with multiple myeloma according to the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Multiple Myeloma (Revised 2020) [Annex 1]; 2. Patients who have undergone more than 6 rounds of current treatment for multiple myeloma such as proteasome inhibitors and iMIDS, or at least 2 relapses after autologous hematopoietic stem cell transplantation, or patients who cannot tolerate treatment with proteasome inhibitors and iMIDS and cytotoxic drugs such as adriamycin and cyclophosphamide for at least one relapse; 3. At least one indicator of multiple myeloma that can be measured and assessed for efficacy: (1) serum M protein >= 0.5g/dL (5g/L); (2) urine M protein >= 200mg/24h; (3) serum free light chain assay: in the case of an abnormal serum free light chain ratio, the level of affected free light chain >= 10mg/dL (100mg/L); (4) the ratio of myeloma cell in tumor tissues greater than or equal to 10% or more, or extramedullary plasmacytoma may be measured.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of allergy to boanmycin; 2.Patients with severe heart failure, respiratory failure, or hepatic failure; 3.Patients with bloodstream infection, infectious shock; 4.Unconscious patients; 5.Patients with central nervous system disorders requiring treatment; 6.Pregnant women; 7.Those who have participated in other clinical trials within one month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of Response;Progression-free Survival;Overall Survival; | — |
Countries
China
Contacts
Public ContactTian Faqing
Longgang District People’s Hospital of Shenzhen
Outcome results
None listed